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Frank, S.J., et al

History of pancreatitis or gallbladder disease, because these conditions may worsen with GLP-1 medications

2022;72 doi: 10.1016/j.jddst.2022.103381

Muscle contractile activity regulates Sirt3 protein expression in rat skeletal muscles

When injected subcutaneously, the peptide reaches peak plasma levels within 1-3 hours and is cleared relatively rapidly, likely through peptidase degradation and renal filtration