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The effects of genetic polymorphisms on the rates of drug metabolism are well known, but how these polymorphisms influence the susceptibility to drug-drug interactions is less clear, in particular considering warfarin-drug interactions, whether reduced function proteins (e.g., CYP2C9*3 ) are inhibited to the same extent in vivo as wild-type proteins (e.g., CYP2C9*1 )

doi: 10.1038/s41421-022-00495-y 457 WuS.SongR.LiuT.LiC

Doses at or below 300 mg/day racemic ALA carry the lowest observable risk profile based on current evidence

formal analysis: N.I.M.F