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Aging cells cannot be stimulating proliferation, it is by a variety of types of damage and stress caused by, not due to terminal differentiation, its characteristic is that through the cell cycle dependent kinase inhibitor p16 and p21CIP1, results in the stagnation of irreversible cell cycle ( Senescent cells can perturb their microenvironment by directly secreting senescence-related factors or by utilizing other means of communication, such as extracellular vesicles, leading to functional degradation (61)

Apigenin, a potent suppressor of dendritic cell maturation and migration, protects against collagen-induced arthritis

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