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10.3390/pharmaceutics13070999 27

The circadian redox rhythm was not observed in arrhythmic BMAL1 / mice, indicating that redox oscillations rely on a functional circadian clock 83

Although both species upregulated their antioxidant defense systems, these responses were inadequate to fully alleviate oxidative injury at higher Pb concentrations

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1 Introduction Cardiovascular diseases (CVDs) are currently considered the leading cause of death worldwide, with approximately 50% of annual deaths attributed to CVDs ( 2 Formation, markers, and cardiac biological functions of neutrophils 2.1 Formation of neutrophils Neutrophils are the most abundant type of leukocytes, constituting the crucial first line of defense against infections, the general life cycle of neutrophils includes their formation in the bone marrow, release into the bloodstream, migration to tissues, and eventual clearance ( 2.2 Heterogeneity and markers of neutrophils The diverse functional responses of neutrophils are triggered by the changes in transcriptional activation and the expression or activity of surface molecules