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Aigner A RNAi-Mediated Gene-Targeting Through Systemic Application of Polyethylenimine (PEI)-Complexed siRNA In Vivo

Notably, enzastaurin showed the most significant effect at a higher concentration of 100 M (Fig

2000 Dec 20;121(1-3):217-30. [PMID: 11164475]

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Specifically, the upregulation of the Nrf2 pathway triggers the production of phase II detoxifying/antioxidant enzymes, such as HO-1 and GSTa, while the downregulation of the TLR2/MyD88/NF-B pathway results in a decreased production of pro-inflammatory cytokines, including IL-1, IL-8, and TNF-