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The enhanced dissolution behavior can be attributed to improved drug solubilization, reduced particle size, and formation of lipidsurfactant hybrid nanostructures, which collectively increase the effective surface area and improve wetting of SIL in aqueous media

In another example of mRNA-based proinflammatory cytokine therapy, engineered IL-2 mRNA was loaded into polyethyleneimine-modified porous silica nanoparticles and delivered via intratumoral injection ( Figure 6B ) (121)

Additionally, Vitamin C will protect against UV damage, Niacinamide will strengthen the skin barrier, and retinoids thicken skin and increase blood flow

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