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Tosco et al., 2018)

Not to be confused with low-dose immunotherapy (LDI), low-dose naltrexone (LDN) is another effective therapy for reducing pain and inflammation induced by Lyme disease Naltrexone is manufactured at a dose of 50mg for alcohol and drug addiction, but when used at much smaller doses, it has a broad range of applications including treatment of autoimmune conditions and pain reduction

Outliers were removed from control data after identification with ROUT Q = 0.5% (number of outliers removed: NAD + /NADH ratio n = 2, NADP + /NADPH ratio n = 11 and GSH/SSG ratio n = 6, no outliers were identified for individual metabolites)

2023 ASCO Annual Meeting 41(16):suppl, 2023

257 Chronic T cell receptor stimulation and nutrient deprivation further promote exhaustion, particularly in CD8 + T effector memory (Tem) cells, which are critical for long-term immune surveillance