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Prdx forward: 5-GGAGGATTGGGACCCATGAAC-3

Nat Rev Immunol (2011) 11(6):40315

Murine models based on Tymp / /Upp / genes double knock-out have been developed to study MNGIE but displayed inconsistencies with the clinic likely due to differences in the deoxyribonucleoside metabolism between humans and mice (Haraguchi et al., 2002)