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Circulating RBCs are subject to a continuous onslaught of endogenous and exogenous oxidative stress, and expectedly more stress is incurred during storage and during the harsh treatment by chemicals and/or exposure to UV lights [35]

Importantly, the observed oxidative damage and mitochondrial impairment following GCLC knockdown were reproduced across multiple assays and time points, reinforcing its critical role in redox regulation and cellular viability [31,32,33]

Statistical analysis A combination of multivariate (orthogonal partial least squares discriminant analysis) and univariate (analysis of variance, linear modeling) approaches was applied to perform group comparisons, following the workflow described by Blaise et al

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However, you are at increased risk of vitamin B12 deficiency if any of the following applies: You're age 50 or older

and (iii) promoting microvascular perfusion by increasing functional capillary density