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The serotonin (5-HT) system, a key mediator of mood regulation, has been extensively probed in animal models

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96 Moreover, in cystic fibrosis transmembrane conductance regulator gene knockout mice, gut microbiota dysbiosis leads to increased neutrophils, macrophages, and T cells in the periportal region of the liver and activates pro-inflammatory and pathogen-mediated immune pathways

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These variations in the kinetics of GDHs can be understood when we consider that GDHs function in both directions, i.e