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doi:10.3233/JAD-2011-110503 Tanaka K, Watase K, Manabe T, Yamada K, Watanabe M, Takahashi K, Iwama H, Nishikawa T et al (1997) Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1

10.1371/journal.pone.0161816 173 ThomasN

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The coronavirus disease 2019 (COVID-19) pandemic has further magnified this burden, as the viruss impact on the central nervous system (CNS) has been linked to mood disturbances, including depression and anxiety [4]

Lill and Freibert, 2020) have observed biochemical and morphological characteristics of ferroptosis in the brains of AD patients or mice, including iron metabolism imbalance, glutathione (GSH) degradation, inactivation of glutathione peroxidase 4 (GPX4) leading to increased reactive oxygen species (ROS), lipid peroxidation, and mitochondrial abnormalities

Future research will be needed to explore each of these potential mechanisms individually or in tandem with each other as protection against glutamate exposure