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The NLRP3inflammasome as a sensor of organelle dysfunction

These DNA-damage recognition proteins have been shown to deliver signals from DNA breaks to downstream proteins such as p53, p73 and mitogen-activated protein kinases (MAPK), which activate apoptosis and other forms of cell death [21]

It is well known that -class glutathione S-transferase 1 (GSTM1) plays an important role in the toxicity and effectiveness of medical drugs

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The Mediterranean and MIND diets are rich in these compounds, which are associated with cardiac and brain health

This minor metabolite is typically harmless, since it is mostly conjugated with glutathione and excreted in bile [13,14]