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An indoleazine alkaloid (2,3-dihydro-1H-indolizinium chloride) extracted from (a fern) had half-maximal inhibitory concentrations with IC50 values 0.3 g/mL and 4.0 g/mL against and , respectively [174]

10.1002/prot.22171 126 RudolphT

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In order to counter the toxic effects caused by cisplatin during therapy, leads to innovation in the therapeutic strategies which includes combination drug therapy with other compounds used in the treatment of different cancers like paclitaxel, doxorubicin, tegafur-uracil, and gemcitabine, along with nanotechnology formulated drugs for boosting the drug delivery of cisplatin and for providing better and less toxic therapy to cancer patients

Triple therapy with osimertinib, bevacizumab and cetuximab in EGFR-mutant lung cancer with HIF-1/TGF- expression