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New ophiobolin derivatives from the marine fungus aspergillus flocculosus and their cytotoxicities against cancer cells

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Tyrosine kinase inhibitor SU11274 increased tumorigenicity and enriched for melanoma-initiating cells by bioenergetic modulation

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A process for obtaining an antibody-drug conjugate according to any one of claims 1-23, wherein the method comprises: culturing a host cell under conditions suitable for production of an anti-FRa antibody as defined in any one of embodiments 1-21 , isolating said anti-FRa antibody, synthesis of exatecan bonded to the linker L of formula (VIII): EXAMPLES Functional Assays Human FRa-binding affinity by ELISA Sandwich ELISA assays are performed using 96-well high-binding ELISA plates (Corning Inc., New York, NY, USA, Cat#3590)