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One specific enzyme, GPx4, plays a vital, non-redundant role in protecting the mitochondria

These often subside with continued use or dose adjustment (starting at 500 mg twice daily with food can improve GI tolerance, then uptitrating to three times daily) (Li et al., 2023)

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In the real world, environmental toxins, your diet, stress, and other lifestyle issues have disabled the checks and balances of this system, encouraging your body to make more of the pro-inflammatory prostaglandins and less of the anti-inflammatory ones

J Chromatogr B Analyt Technol Biomed life Sci 851:5170