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Spermidine, synthesized from putrescine by the addition of an aminopropyl group, displays greater physiological specificity and regulates key processes such as translation, membrane stability, and autophagy 21

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Indeed, the clinical literature exhibits heterogeneity in design, dosing, duration, and outcome measures, frequent reliance on parent reported scales without uniform blinding, and underpowered samples that hinder strong inference and guideline development (Doherty et al., 2022