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Another is the development of more efficient delivery systems, particularly for systemic therapies, to ensure adequate bioavailability

2.1.4.1 The engineering continuum: coupling constraint to functional agnosticism Virus-like particle functionalization strategies can be conceptualized along a continuum defined by the degree of thermodynamic coupling between scaffold assembly and antigen incorporation: Genetic fusion (the fully coupled regime): this remains the most structurally deterministic strategy, ensuring strict 1:1 stoichiometry and genetic stability

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Furthermore, this review provides a perspective for future research that may contribute to the development of new drugs for neurodegenerative disease treatments