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However, there have been no clinical trials that have evaluated and validated these compounds in SCA3 patients 31

The effects exceeded those of vitamin C and retinoic acid in comparative analysis

Thats the whole problem with it

For example, women with Hashimoto's thyroiditis receiving selenium reported better emotional regulation and cognitive clarity in addition to biochemical changes (198)

Among these nanosytsems, polymer-based carriers, including polycaprolactone (PCL), polyethylene glycol (PEG), and chitosan, PLGA, offered an attractive biodegradable platform for encapsulating both synthetic drugs and bioactive natural compounds 29