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[,,,] Mechanistically, Them2 limits the rates of fatty acid oxidation in the skeletal muscle, thus, decreases the demand by the skeletal muscle for fatty acids in the form of secreted hepatic VLDL TG

designed a stapled peptide targeting EFHD2, which inhibited ferroptosis and alleviated fibrosis progression in NASH [221]

Anti-apoptosis effects Based on our previous research, Tauroursodeoxycholic acid (TUDCA) can decrease neuronal apoptosis and enhance hippocampal synaptic plasticity by inhibiting endoplasmic reticulum stress activation (Xu et al., 2015)

Experts recommend high-calorie diets (around 3540 kcal per kilogram of body weight per day), often with a high-fat content, which might offer some protective effects on nerve cells (Guillemin et al., 2022)

ContardiMLenzuniMFiorentiniFSummaMBertorelliRSuaratoGet al

Energetically favorable literally means that it has a more negative Gibbs free energy, which typically means that the protein is more compact and makes more interactions with itself, like in the rough sketch of a protein on the right side of Figure 6