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After restoring the expression level of p53 in A549 cells, the sensitivity of cancer cells to radiotherapy significantly increased, and significant lipid peroxidation was observed in wild-type p53-expressing A549 cells after adding Nutlin, an inhibitor of MDM2

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Pesticides can disturb oxidative homeostasis through direct or indirect pathways, including mitochondrial or extramitochondrial production of free radicals, thiol oxidation, and depletion of cellular antioxidant reservoirs

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