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Firstly, assuming that mitochondria are the main source of endogenous free radicals [239,240], it has been previously reported that species with higher metabolic rates have shorter maximum lifespan due to superoxide anion radical accumulation that lead to cell damage, hastening aging [241]

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By that I mean that by combining the two, they work synergistically to provide benefits that would otherwise be impossible to achieve with each compound used on their own separately

A protein localization-dependent sensor also was developed for corticosterone detection in animals[109]

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