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The interaction of MPH with several proteins involved in the neurotransmission process could explain its MoA (Fig

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However, the emergence of viral variants, particularly Omicron strains with more than 30 mutations in the spike protein, has diminished the efficacy of several marketed antibodies, driving the development of therapeutics with broader neutralizing capabilities 47

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Notably, certain plant-derived metabolites activate neuroprotective signaling pathways, such as the MAPK/NF-B system, (Md et al., 2021), and interact with estrogen receptor beta (ER), a known regulator of synaptic plasticity and neuroprotection ( 4.6 Overcoming challenges in translating natural compounds into clinical applications Despite promising findings, translating the therapeutic potential of natural compounds into clinical practice presents several key challenges