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10.1016/s0891-5849(99)00104-5 70 Gediz ErturkA.SahinA.Bati AyE.PelitE.BagdatliE.KuluI.et al (2021)

These visible markers can diminish our perceived vitality and confidence

At physiological pH, the cysteine thiol (pKa ~8) is substantially more nucleophilic than the lysine amine (pKa ~10.5), making non-enzymatic acetylation of cysteine thermodynamically and kinetically favored 31

The development of DNA methylation-based epigenetic clocks that reflect aging, when combined with disease-specific DNA methylation alterations, holds promise for identifying biomarkers and predicting disease risk (Horvath and Raj, 2018

132 Madera-SalcedoI

in patients in whom the histological examination of the explanted liver revealed PAS-D (Periodic Acid-Schiff Diastase) positive granules in the cytoplasm of hepatocytes