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demonstrated the cystine residue C466 on the Src family kinase Lyn as being the direct target of H 2 O 2 to induce neutrophil recruitment to the wound site, mediated through ERK signalling 16

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While natural IgG1 antibodies have a half-life of 3 weeks on average, individual monoclonal IgG1s have strikingly different half-lives, ranging from 632 days, while Fc-fusions mostly have shorter half-lives than IgG1 3,13

17 In addition, abnormal lipid metabolism, such as phosphatidic acid choline metabolism disorder 18 and decreased desaturase activity, 19 may lead to a decrease in alveolar surfactant, which in turn aggravates lung damage in ARDS patients

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