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This indicates that NCOA4 functions upstream of SFXN1 and implicates NCOA4-mediated autophagy and ferroptosis in the development of cardiac hypertrophy [159, 160]

Furthermore, emerging evidence has suggested that PLIN2,RAB7A and ATG5 mediating lipophagy regulation are the key points in modulating cellular sensitivity to ferroptosis [86]

The aforementioned anti-inflammatory characteristics are especially relevant in cases of chronic pain, as neuroinflammation plays a role in the persistence of pain signals

Therefore, these nanoparticles integrate tumor-selective activation, multi-modal cell-killing, microenvironment modulation, and immune potentiation into a single programmable platform, which suppresses primary and metastatic tumors sustainably with the minimum systemic toxicity

In breast cancer, lutein induces cell cycle arrest and apoptosis (cell death) of cancer cells which significantly prevents the growth of breast cancer cells (21)

& Elsherif, D