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Ipamorelin | Mechanism of Action Hexarelin targets receptors GHSR-1a and CD-36

Cardiovascular Med

It binds to growthhormone secretagogue receptors (GHSR) in the hypothalamus and pituitary, reduces the inhibitory signal from somatostatin, and triggers a rapid GH pulse

Secondly, cycling Ipamorelin use can help prevent desensitization of the GH receptors, which can occur with prolonged and continuous usage

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A separate study showed that methylprednisolone did not block ipamorelin's GH-releasing effect despite suppressing endogenous GH secretion, demonstrating that the GHS-R1a pathway can override glucocorticoid-mediated GH suppression