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Indirect manipulation of the dopaminergic system is also caused by the methionine-cholinefolate deficient diet (MCFD)

doi: 10.1186/s12943-020-01247-w 271 AmouzegarAChelvanambiMFildermanJNStorkusWJLukeJJ

After entering the thyroid follicle (or thyroid follicular cell) via a Na + /I symporter (NIS) on the basolateral side, iodide is shuttled across the apical membrane into the colloid via pendrin, after which thyroid peroxidase oxidizes iodide to atomic iodine (I) or iodinium (I + )

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However, after long-term exposure to stress environment and induced TP53-mediated apoptosis, the expression of TIGAR decreased, suggesting that the induced apoptosis might reflect the loss of protection of survival signal induced by TP53 (Bensaad et al., 2006)