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Unfortunately, as there is no clear guidance, consideration on a patient-by-patient basis is required

When performed, this test can diagnose and show the extent of nerve injury

Some individuals develop a small area of redness or swelling at the injection site after IM administration

A 2025 meta-analysis pooling three trials (878 participants) confirmed the pattern: significantly greater weight loss than placebo about ~14% of total body weight on average with no significant rise in overall adverse events [6] [7]

Long-lasting effect Sustains anesthesia for the duration of minor procedures

But getting it wrong has consequences that compound with every injection