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Controlled levels of mitochondria-derived ROS act as signaling molecules during oocyte maturation, activating pathways such as MAPK/ERK to facilitate meiotic progression [33]

Sitkowska, K., Feringa, B

When the ratio of AMP (or ADP) to ATP is increased, which in turn triggers the AMP-activated protein kinase pathway, the exact mechanism of action of AMPK in oocyte senescence is not clear, thereby providing a potential direction for future research

doi: 10.3390/molecules26102941 456 ZhangYGuJWangYZhaoZWangZLiW

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