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Therefore, these results could reasonably indicate that Car@Deu@PEPS is a biocompatible product with minimal skin irritation and negligible toxicity, demonstrating its further potential for achieving the topical application of deucravacitinib in clinical practice

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Acknowledgements We would like to thank the College of Agriculture, Isfahan University of Technology for the financial support to conduct this study and the help of several colleagues during the experimental work

A century ago, three-quarters of prescriptions required some sort of in-pharmacy compoundingmixing up drug formulations in the shop rather than giving a patient a standard off-the-shelf medicationbut that number dropped to 1% by the 1970s