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Astrocytes and neurons contain glutamine transporters, whichunder appropriate electrophysiological conditionsresult in a net exchange of glutamine between astrocytes and neurons

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With the deepened comprehension of molecular mechanism, glutathione peroxidase 4 (GPX4) has been thoroughly reported as a key regulator for protecting cells from toxic lipid hydroperoxides of ferroptosis, which is highly expressed in tumor tissues compared with that in adjacent normal tissues 3,4,5

However, they may not be suitable for individuals with metal allergies, particularly to copper, or those with highly sensitive or compromised skin

This risk is particularly concerning with chronic use or in individuals with family histories of cancer or existing malignancies

Given the complex interrelationships among NAD + metabolism, mitochondrial function, and redox homeostasis, the uncontrolled supplementation of these elements may paradoxically lead to the exacerbation of oxidative stress or the impairment of cellular balance in individuals who are predisposed to such conditions