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Proc Natl Acad Sci USA 2003;100:5107-5112

NPI-001 depleted cystine from human cystinosis fibroblast cells in culture statistically significantly greater than cysteamine

Furthermore, studies cited in other reviews (Wirbisky and Freeman, 2015

There are some genetic predispositions

J Toxicol Environ Health A 69 : 12611284 Brown LA, Ping XD, Harris FL, Gauthier TW 2007 Glutathione availability modulates alveolar macrophage function in the chronic ethanol-fed rat