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MicroRNAs (miRNAs) are a class of small, single-stranded non-coding RNAs that plays a crucial role in post-transcriptional control: it is estimated that they regulate the expression of at least 30% of mammalian genes [145]

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Additionally, metformin administration significantly increased SOD activity in MIA-induced OA mice, no significant change was observed in GSH-PX levels (Fig

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