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MMPs (such as MMP-1, -2, -3, -7, -9, -13, 14, and ADAMTS-4) are upregulated in IDD and correlate with the severity of degeneration (Zhang C

The clinical use track record in Eastern Europe and Asia provides a level of real-world safety and efficacy data that purely preclinical peptides lack, though large-scale randomized controlled trials specifically for peripheral neuropathy are still needed