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NICE-approved weight management interventions include: Dietary and lifestyle modification first-line approach for all patients Orlistat licensed medication for obesity (BMI 30 or 28 with comorbidities) GLP-1 receptor agonists including semaglutide (Wegovy) per NICE TA875 and liraglutide (Saxenda) with restrictions per NICE TA664, for specific patient groups Bariatric surgery for severe obesity meeting strict criteria The NHS emphasises that sustainable weight loss requires behavioural change, nutritional education, and increased physical activity

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These protocols are derived from animal study dose extrapolation and have no basis in controlled human research

Symptoms during initiation of a ketogenic diet: a scoping review of occurrence rates, mechanisms and relief strategies

Most users report faster return to activity compared to previous similar injuries treated conservatively

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