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Description

As the sole intracellular LPO-reducing enzyme, the lack of GPX4 results in excessive accumulation of LPO, destabilizing biological membranes, exacerbating oxidative stress, and ultimately promoting ferroptosis (Ursini and Maiorino, 2020)

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JCI Insight 4:e130111 Mizzi N, Blundell R (2025) Glycine receptors: structure, function, and therapeutic implications

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