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The usual concern with regards to treatment with IGF-1 has historically been hypoglycaemia, however in the trials done so far it has not always occurred and had been lessened when administered with mealsit was also usually connected to an appearance in a loss of appetite [264, 286]

The deficiency of neurotrophic support leads to neuronal atrophy, impaired axonal transport, and decreased nerve regeneration capacity

This weight loss was likely due to a combination of reduced appetite and increased energy expenditure

Nicotinamide is less likely to cause skin flushing and negative health effects

Biology 9 (11), 363