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Even with its complex etiology, genetics is a major factor in the course of the illness [15]

Moreover, homocysteine and methionine compete for the same amino acid transporter so, high homocysteine will mean low methionine uptake 41 , further hampering the OCM

Some studies suggest that high concentrations of BCAAs selectively disrupt mitochondrial pyruvate utilization in a mouse model of ischemic heart injury (Li et al., 2017), while others showed that a BCAA-enriched mixture increased the average lifespan of mice, increased mitochondrial biogenesis and sirtuin one expression in primary cardiac and skeletal myocytes and in cardiac and skeletal muscle of middle-aged mice, and upregulated reactive oxygen species defense system genes (DAntona et al., 2010)

2022;119: e2109617119

88], because it reacted violently with mercury(II) oxide ("deutoxide de mercure") [p

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