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By combining Keap1 inhibitors with H2S-donor moieties via molecular hybridization, DDO-1901 showed enhanced efficacy in alleviating colitis by mitigating oxidative stress and inflammation, outperforming parent drugs alone (263)

Results Mdr2 / EHBDs demonstrate progressive damage over time Sections of EHBDs from WT mice showed stable duct morphology from age 2- to 40- weeks, with oval duct lumens set in bland fibrous stroma, lined by regular, cuboidal-to-columnar biliary epithelial cells

A study by Shin et al

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Cell Death Dis 2018, 9:114