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Description

Accumulation of ARG1 has been shown to drive polyamine production from the urea cycle (Lou et al., 2020)

This highlights the importance of carefully accounting for external factors, such as medication use, when interpreting metabolomic data to prevent confounding effects that could obscure biologically meaningful results

Preclinical research links it to three main mechanisms: VEGFR2/eNOS angiogenic signaling, Src-caveolin-1-eNOS nitric oxide modulation, and FAK/paxillin cell-migration signaling