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a , Lung metastases observed 30 days post-tail-vein-injection: 12/13 mice injected with Ecad cells developed metastasis, whereas no metastasis was observed in 0/6 mice with Ecad cells, b , Time to reach 1 cm tumor volume in neck-graft reimplantations of male and female Ecad and Ecad melanoma in male and female C57BL/6 J mice, respectively