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Nausea, vomiting, diarrhea, and constipation are common, especially in the early weeks of treatment

Tell your clinician about any medicines that may affect vitamin B12 or folate testing, such as antibiotics, methotrexate, pyrimethamine, colchicine, para-aminosalicylic acid, or heavy alcohol use

Many people notice a real energy boost within hours of their first shot, though most feel a clear shift within the first week or two

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The 2024 NICE guideline asks clinicians to tailor timing to your symptoms and review it, rather than treating one figure as fixed

That candor is part of why patients keep coming back to this treatment