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In addition, dichloroaceetate treatment alone caused ER stress to an extent that was nearly as robust as the bona fide ER stressor TM, as seen by upregulation of UPR target genes (Figure 7B) and splicing of Xbp1 (Figure 7C)

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For IHS and Tribal hospitals and Puerto Rico hospitals, we finalized the use of a low-income insured days proxy to determine Factor 3 for FY 2021(85 FR 58825)

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