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A., Matot, E., Malka, G., Kosower, N., Rein, M., Zilberman-Schapira, G., Dohnalov, L., Pevsner-Fischer, M., Bikovsky, R., Halpern, Z., Elinav, E., & Segal, E

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Huber, K., Muscher, A

Keywords: prolyl hydroxylase domain (PHD), hypoxia-inducible factor (HIF), metabolism, mouse models, hydroxylation, 2-oxoglutarate-dependent dioxygenases Introduction Low oxygen (O 2 ) and nutrient availability are often encountered in solid tumors due to abnormal vasculature and rapid proliferation of cancer cells