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Scientific Reports , 10

20 Effect of c-Met knock-down on spinogenesis using a shRNA

The relationship between the C max , AUC, total clearance, and renal clearance of lesinurad and creatinine clearance (CrCl) is shown in Figure 2

Hinge DYIRNC, SEQ ID NO: 3 MDCK Madin-Darby canine kidney Hinge was tested for its effects on dissociated hippocampal neurons and was found to have no effect on spinogenesis over a wide range of doses, thus indicating that Hinge and the HGF/c-Met system do not have a significant role in the basal spinogenesis seen in the cultured neurons (Figure 13A)

Before the vote, the committee discussed the use of the peptide for the treatment of ulcerative colitis, a common type of inflammatory bowel disease that can cause inflammation and ulcers in the colon