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Success in EB applications could also inform development strategies for T4 in other rare diseases characterized by impaired tissue repair or maintenance, expanding the therapeutic impact of this versatile peptide beyond more common indications

These effects were observed also in PCOS mice receiving the second formulation containing 0.40 mg LC, 0.20 mg ALC, and 0.08 mg PLC (mouse/day), where a decrease in serum levels of testosterone was also reported

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Combined interventions targeting MPC dysfunction, ROS buffering systems such as the Nrf2GSH axis, or mitophagy pathways including PINK1, may disrupt the self-sustaining signalmetabolism circuit and offer a strategy to delay or reverse acquired therapeutic resistance

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