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Caspase-1 expression resulted in WT IL-1 cleavage into its active p17 fragment, which was detected in both cell lysates and supernatants and, as expected, its processing was blocked by treatment with the pan-caspase inhibitor ZVAD-fmk (Fig

Hatcher, and R

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Thus, our results suggest that ferroptosis plays a key role in motor neuron degeneration of ALS

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The occurrence and development of different diseases are associated with abnormal GSH metabolism through different mechanisms: Glutathione dynamics during sepsis Sepsis is characterized by severe redox imbalance, and glutathione plays a key role in combating oxidative and nitrosative stress