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Although proximal steps (upstream events) in the development of DILI are likely to be drugs/class specific, distal steps (downstream events) are likely to be shared by DILI due to multiple drugs, so may have common biomarkers

These systems interact closely, exhibiting functional overlap and mutual support

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In this biosynthesis process, methionine is a critical source of cysteine to synthesize glutathione through methionine adenosyltransferase, S-adenosylhomocysteine hydrolase, cystathionine -synthase, cystathionine -lyase, GS, and so on [32]

They are needed for the maintenance of muscle during physical stress and exercise