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Nature 508, 258262

it is also a major NAD + consumer with a lower K m than most NAD + -consuming enzymes 40 and is implicated in the decline of NAD + levels observed during aging and disease 5052

The current paradigm is that compromised V-ATPase function impairs starvation-induced autophagy 16 , because most lysosomal/vacuolar hydrolytic enzymes have optimal activity at acidic pH 17