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For example, in a 2021 randomized, controlled trial, 100-200mg of dihydroberberine yielded higher blood levels of berberine than 500mg of the standard stuff

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Advances in supplement formulation may improve oral delivery in the future

Dietary supplementation with curcumin reduce circulating levels of glycogen synthase kinase-3 and islet amyloid polypeptide in adults with high risk of type 2 diabetes and Alzheimer's disease